Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077312 | 1.00 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL8355465 | 1.00 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL2825572 | 1.00 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL4170101 | 0.95 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL3924518 | 0.95 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL7752203 | 0.90 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL8355484 | 0.86 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL3924523 | 0.85 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL4170092 | 0.85 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2BTSHR | |
| SCHEMBL13873935 | 0.83 | ADORA1 (0.49) | ADORA1ADORA3ADORA2AADORA2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101119718-B | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics | SOLVAY PHARM GMBH | 2011-06-15 | — | — | CN | disclosed |
| CN-101119718-A | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics | SOLVAY PHARM GMBH (DE) | 2008-02-06 | — | — | CN | disclosed |
| EP-1853270-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEP-INHIBITORS, INHIBITORS OF THE ENDOGENOUS ENDOTHELIN PRODUCING SYSTEM AND DIURETICS | Solvay Pharmaceuticals GmbH (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006087371-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEP-INHIBITORS, INHIBITORS OF THE ENDOGENOUS ENDOTHELIN PRODUCING SYSTEM AND DIURETICS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2006-08-24 | — | — | WO | disclosed |