Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170092 | 0.89 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL3924523 | 0.89 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL5189246 | 0.86 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL4077312 | 0.86 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL2825572 | 0.86 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL8355465 | 0.86 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL3924518 | 0.84 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL4170101 | 0.84 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL4083747 | 0.79 | ELANE (0.51) | ADORA1ADORA3ADORA2AADORA2BJAK3 | |
| SCHEMBL7752203 | 0.78 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450811-B1 | Compounds specific to adenosine A1 and A3 receptors and uses thereof | OSI PHARM INC (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-2050751-A1 | Compounds specific to adenosine A1 and A3 receptors and uses thereof | OSI Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2003048120-A2 | 2-ARYL PYRROLOGPYRIMIDINES FOR A1 AND A3 RECEPTORS | OSI PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |