SCHEMBL5189274

SCHEMBL5189274

CC/C(OC)=C(\C(=O)O)c1ccccc1Oc1cc(Oc2ccccc2C#N)ncn1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 1/20 0.40
ALDH1A1 P00352 2/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
SYK P43405 1/20 0.38
NPC1 O15118 4/20 0.38
RAB9A P51151 4/20 0.38
SMN1; SMN2 Q16637 4/20 0.37
MAPK1 P28482 1/20 0.37
MAP4K4 O95819 1/20 0.37
MAPK14 Q16539 2/20 0.36
KDM4E B2RXH2 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
GAA P10253 2/20 0.35
POLB P06746 1/20 0.35
IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5189282 1.00 PIN1 (0.40) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL5189278 0.88 PIN1 (0.39) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL205372 0.87 PIN1 (0.46) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL2837438 0.87 PIN1 (0.46) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL3958269 0.86 PIN1 (0.41) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL205371 0.85 PIN1 (0.41) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL899337 0.84 KDM4E (0.40) PIN1ALDH1A1HPGDSYKNPC1
SCHEMBL899340 0.84 KDM4E (0.40) PIN1ALDH1A1HPGDSYKNPC1
SCHEMBL9494059 0.80 MAP4K4 (0.41) PIN1ALDH1A1HPGDTSHRSYK
SCHEMBL3958493 0.79 PIN1 (0.41) PIN1ALDH1A1HPGDTSHRSYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1791427-A1 (HETERO)CYCLYLCARBOXAMIDES FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2007-06-06 EP disclosed
WO-2006027198-A1 (HETERO)CYCLYLCARBOXAMIDES FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2006-03-16 WO disclosed