Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TLR4 | O00206 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.52 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | GART | P22102 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430182 | 1.00 | DHFR (0.56) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL5189458 | 1.00 | DHFR (0.56) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| Bromide SCHEMBL8420545 | 0.99 | DHFR (0.55) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL14987839 | 0.96 | DHFR (0.61) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL8051870 | 0.92 | DHFR (0.50) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL7162992 | 0.88 | DHFR (0.58) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL8420248 | 0.88 | DHFR (0.47) | DHFR | |
| SCHEMBL7164303 | 0.83 | DHFR (0.64) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL8446723 | 0.82 | DHFR (0.62) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL8448527 | 0.81 | DHFR (0.61) | DHFRKDM4ETLR4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270441-A1 | Combination | ALTANA PHARMA AG (DE) | 2007-11-22 | — | — | US | disclosed |
| EP-1448202-A1 | COMBINATION OF A PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA Pharma AG (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003039552-A1 | COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA PHARMA AG (DE) | 2003-05-15 | — | — | WO | disclosed |
| US-20030092706-A1 | Combination | NYCOMED GMBH (DE) | 2003-05-15 | — | — | US | disclosed |