Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 13/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191267 | 0.90 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5191811 | 0.90 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5189285 | 0.89 | ADORA2A (0.47) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5193776 | 0.87 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5190711 | 0.86 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5191092 | 0.84 | BRD4 (0.48) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5191300 | 0.84 | ADORA2A (0.42) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5191233 | 0.83 | ADORA2B (0.56) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL5189467 | 0.83 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3BRD4 | |
| SCHEMBL5191409 | 0.81 | ADORA2A (0.44) | ADORA2BADORA2AADORA1ADORA3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439176-B1 | PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | EISAI R&D MAN CO LTD (JP) | 2007-03-21 | — | — | EP | disclosed |
| EP-1439176-B1 | PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | EISAI R&D MAN CO LTD (JP) | 2007-03-21 | — | — | EP | disclosed |
| US-7160892-B2 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-7160892-B2 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-1439176-A1 | PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2004-07-21 | — | — | EP | disclosed |