Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419786 | 0.90 | KMT2A (0.58) | KMT2APAX8MAOAMAOBNFKB1 | |
| SCHEMBL30068472 | 0.90 | KMT2A (0.58) | KMT2APAX8MAOAMAOBNFKB1 | |
| SCHEMBL2725231 | 0.90 | KMT2A (0.58) | KMT2APAX8MAOAMAOBNFKB1 | |
| SCHEMBL5188736 | 0.81 | KMT2A (0.49) | KMT2APAX8MAOAMAOBNFKB1 | |
| SCHEMBL31035850 | 0.81 | TDP1 (0.59) | HPRT1PAX8MAOAMAOBTDP1 | |
| SCHEMBL5672210 | 0.81 | TDP1 (0.59) | HPRT1PAX8MAOAMAOBTDP1 | |
| SCHEMBL13085233 | 0.79 | HPRT1 (0.70) | HPRT1KMT2APAX8TDP1LMNA | |
| SCHEMBL3362663 | 0.78 | TDP1 (0.61) | HPRT1PAX8MAOAMAOBTDP1 | |
| SCHEMBL30450770 | 0.78 | TDP1 (0.61) | HPRT1PAX8MAOAMAOBTDP1 | |
| SCHEMBL30588914 | 0.78 | TDP1 (0.61) | HPRT1PAX8MAOAMAOBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000025-B1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2007-02-21 | — | — | EP | claimed |
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | claimed |
| EP-0801750-B1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG IND OHIO INC (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-0801750-A4 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES INC (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0801750-A1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996004576-A1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES, INC. (US) | 1996-02-15 | — | — | WO | disclosed |