Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5189818 | 1.00 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4825120 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4825122 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8269860 | 0.86 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4816890 | 0.85 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4816894 | 0.85 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5193866 | 0.85 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4823570 | 0.84 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8269901 | 0.83 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8271372 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |