Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.71 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193866 | 1.00 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL4816894 | 1.00 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL5189807 | 0.85 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5189818 | 0.85 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4825120 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL4825122 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL4824331 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL4824340 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL5193830 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL4816638 | 0.80 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2008-05-15 | — | — | US | disclosed |
| US-7312241-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1603864-A4 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORP (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| EP-1603864-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-01-20 | — | — | US | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.