Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 7/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5189982 | 0.91 | NOS2 (0.47) | OGAKMT2AMEN1HPGDPOLB | |
| SCHEMBL5190648 | 0.85 | POLB (0.47) | OGAKMT2AMEN1HPGDPOLB | |
| SCHEMBL5190108 | 0.84 | NOS2 (0.55) | NOS2NOS1ALDH1A1 | |
| SCHEMBL5189995 | 0.80 | OGA (0.56) | OGAHPGDPOLBNOS2 | |
| SCHEMBL5193596 | 0.79 | NOS2 (0.55) | OGAHPGDPOLBNOS2NOS1 | |
| SCHEMBL5192618 | 0.75 | OGA (0.49) | OGAHPGDPOLBNOS2CYP1A2 | |
| SCHEMBL5190558 | 0.74 | NOS2 (0.65) | NOS2 | |
| SCHEMBL5194974 | 0.74 | NOS2 (0.49) | HPGDNOS2NOS1ALDH1A1CYP1A2 | |
| SCHEMBL5190586 | 0.73 | NOS2 (0.54) | HPGDPOLBNOS2NOS1 | |
| SCHEMBL27436105 | 0.73 | OGA (0.47) | OGAKMT2AHPGDPOLBNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754703-A2 | N-Heterocyclic derivatives as nos inhibitors | Berlex, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| EP-1754703-A2 | N-Heterocyclic derivatives as nos inhibitors | Berlex, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-0968206-B1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LAB (US) | 2006-11-15 | — | — | EP | disclosed |