Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191050 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL4992230 | 0.82 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4992218 | 0.82 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5191708 | 0.82 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4816708 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4816711 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6904789 | 0.80 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL6904792 | 0.80 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5281129 | 0.80 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL4991343 | 0.80 | POLB (0.60) | CYP3A4MAPTALDH1A1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |