Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.74 |
| ▸ | GAA | P10253 | 7/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
| ▸ | KLK7 | P49862 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | PRNP | P04156 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461418 | 0.89 | KDM4E (0.74) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL30064775 | 0.89 | KDM4E (0.74) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL13312183 | 0.86 | MEN1 (0.74) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23722824 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23722906 | 0.80 | KDM4E (0.77) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL17308323 | 0.80 | MEN1 (0.80) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL379807 | 0.79 | LMNA (0.76) | KDM4EMEN1KMT2ALMNARXFP1 | |
| SCHEMBL29586433 | 0.79 | LMNA (0.76) | KDM4EMEN1KMT2ALMNARXFP1 | |
| SCHEMBL10612809 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23722902 | 0.78 | KDM4E (0.72) | KDM4EALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812398-A1 | COMPOUNDS HAVING ACTIVITY AT NK3 RECEPTOR AND USES THEREOF IN MEDICINE | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050992-A1 | COMPOUNDS HAVING ACTIVITY AT NK3 RECEPTOR AND USES THEREOF IN MEDICINE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |
| EP-1812398-A1 | COMPOUNDS HAVING ACTIVITY AT NK3 RECEPTOR AND USES THEREOF IN MEDICINE | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006050992-A1 | COMPOUNDS HAVING ACTIVITY AT NK3 RECEPTOR AND USES THEREOF IN MEDICINE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |