Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.57 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281129 | 0.87 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL5191755 | 0.86 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5607386 | 0.86 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4821919 | 0.82 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4821925 | 0.82 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4991343 | 0.81 | POLB (0.60) | MAPTALDH1A1 | |
| SCHEMBL4991334 | 0.81 | POLB (0.60) | MAPTALDH1A1 | |
| SCHEMBL5190968 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5191050 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL5189819 | 0.78 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |