Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193908 | 0.72 | LMNA (0.42) | LMNAKMT2ACYP2C19NPSR1MEN1 | |
| SCHEMBL20034965 | 0.68 | LMNA (0.57) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL5190982 | 0.68 | CYP2C19 (0.39) | LMNAKMT2ACYP2C19NPSR1MEN1 | |
| SCHEMBL1564353 | 0.67 | KMT2A (0.55) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL5195326 | 0.66 | LMNA (0.39) | LMNAKMT2ACYP2C19 | |
| SCHEMBL4579499 | 0.65 | CYP2C19 (0.51) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL1576048 | 0.64 | LMNA (0.52) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL10272740 | 0.64 | TDP1 (0.62) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL1564349 | 0.64 | CYP2C19 (0.56) | LMNAKMT2ACYP2C19NPSR1TDP1 | |
| SCHEMBL4089086 | 0.64 | LMNA (0.51) | LMNAKMT2ACYP2C19NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |