Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.54 |
| ▸ | FLT1 | P17948 | 9/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5189495 | 0.83 | AURKA (0.49) | AURKAAURKBITKCHEK1CDK2 | |
| SCHEMBL5188932 | 0.83 | PDE4A (0.50) | AURKAAURKBCDK2PAK4FLT3 | |
| SCHEMBL4888424 | 0.81 | CHEK1 (0.53) | PDPK1CHEK1CDK2JAK2PAK4 | |
| SCHEMBL4892869 | 0.81 | CHEK1 (0.62) | CHEK1CDK1KDR | |
| SCHEMBL4896307 | 0.81 | CHEK1 (0.52) | ITKCHEK1CDK1KDRFLT3 | |
| SCHEMBL4931239 | 0.81 | MAPK3 (0.54) | ITKCHEK1CDK2PAK4FLT3 | |
| SCHEMBL10557813 | 0.80 | PDE4A (0.53) | AURKAAURKBFGFR1CDK2ABL1 | |
| SCHEMBL10375588 | 0.80 | PDE4A (0.71) | AURKAAURKBCHEK2PDE4APDE4B | |
| SCHEMBL4888954 | 0.80 | FGFR1 (0.51) | AURKAAURKBFGFR1FLT1ITK | |
| SCHEMBL4885470 | 0.80 | FGFR1 (0.51) | AURKAAURKBFGFR1FLT1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | claimed |
| EP-1831224-A2 | TRYCYCLIC HETEROCYCLES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | disclosed |
| WO-2006063841-A2 | TRYCYCLIC HETEROCYCLES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | CYP11B1, CYP11B2, CYP3A43 | AURKA 2529/4885AURKB 2155/4885FGFR1 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.