Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 16/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191340 | 0.96 | NOS2 (0.56) | NOS2NOS1 | |
| SCHEMBL5192349 | 0.91 | NOS2 (0.46) | NOS2HTT | |
| SCHEMBL5192204 | 0.88 | NOS2 (0.44) | NOS2 | |
| SCHEMBL5190216 | 0.88 | NOS2 (0.45) | NOS2 | |
| SCHEMBL5193161 | 0.87 | NOS2 (0.49) | NOS2 | |
| SCHEMBL5192066 | 0.84 | NOS2 (0.66) | NOS2NOS1 | |
| SCHEMBL5190610 | 0.84 | NOS2 (0.65) | NOS2NOS1HTT | |
| SCHEMBL5192623 | 0.83 | NOS2 (0.55) | NOS2NOS1MEN1USP2KMT2A | |
| SCHEMBL5192225 | 0.83 | NOS2 (0.53) | NOS2NOS1 | |
| SCHEMBL5191677 | 0.82 | NOS2 (0.62) | NOS2NOS1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754703-A2 | N-Heterocyclic derivatives as nos inhibitors | Berlex, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| EP-1754703-A2 | N-Heterocyclic derivatives as nos inhibitors | Berlex, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-0968206-B1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LAB (US) | 2006-11-15 | — | — | EP | disclosed |
| CN-1100777-C | N-heterocyclic derivatives as NOS inhibitor | BERLEX LAB (US) | 2003-02-05 | — | — | CN | disclosed |
| CN-1252799-A | N-heterocyclic derivatives as NOS inhibitor | BERLEX LAB (US) | 2000-05-10 | — | — | CN | disclosed |