Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 11/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.57 |
| ▸ | CDK2 | P24941 | 6/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195304 | 0.91 | FLT3 (0.69) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5196709 | 0.89 | NPC1 (0.49) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5194104 | 0.88 | NPC1 (0.58) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5196094 | 0.87 | NPC1 (0.57) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5195961 | 0.87 | NPC1 (0.57) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5193656 | 0.87 | FLT3 (0.56) | FLT3PDGFRACDK2CCNE1SRC | |
| SCHEMBL5194070 | 0.87 | FLT3 (0.64) | NPC1FLT3PDGFRACDK2CCNE1 | |
| SCHEMBL5626392 | 0.85 | FLT3 (0.55) | NPC1POLBCDK5CDK5R1FLT3 | |
| SCHEMBL5195445 | 0.85 | SCTR (0.63) | NPC1FLT3PDGFRACDK2CCNE1 | |
| SCHEMBL5197924 | 0.85 | CDK1 (0.60) | NPC1CDK5FLT3PDGFRACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | disclosed |
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | disclosed |