Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | CHKA | P35790 | 1/20 | 0.45 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195286 | 0.91 | NPC1 (0.57) | NPC1AURKAYTHDC1SRCFLT3 | |
| SCHEMBL5196709 | 0.90 | NPC1 (0.49) | NPC1YTHDC1SRCFLT3PDGFRA | |
| SCHEMBL5627809 | 0.90 | NPC1 (0.55) | NPC1AURKAYTHDC1SRCFLT3 | |
| SCHEMBL5192781 | 0.88 | NPC1 (0.62) | NPC1YTHDC1SRCFLT3PDGFRA | |
| SCHEMBL5629622 | 0.86 | NPC1 (0.52) | NPC1YTHDC1SRCFLT3POLB | |
| SCHEMBL5194070 | 0.85 | FLT3 (0.64) | NPC1SRCFLT3PDGFRACDK2 | |
| SCHEMBL5197866 | 0.84 | CDK1 (0.59) | YTHDC1CDK5ADORA3 | |
| SCHEMBL6944005 | 0.84 | NPC1 (0.62) | NPC1SRCFLT3PDGFRACDK2 | |
| SCHEMBL5195931 | 0.82 | PDGFRA (0.77) | SRCFLT3PDGFRACDK2CCNE1 | |
| SCHEMBL5195943 | 0.82 | PDGFRA (0.77) | SRCFLT3PDGFRACDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | disclosed |
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | disclosed |