Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106088 | 1.00 | HTR4 (0.43) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL6021882 | 1.00 | HTR4 (0.43) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL1830896 | 0.80 | HTR4 (0.44) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL1831926 | 0.80 | HTR4 (0.44) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL4781372 | 0.80 | DRD3 (0.43) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL1830029 | 0.80 | DRD3 (0.43) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL1833082 | 0.80 | HTR4 (0.44) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL4781369 | 0.80 | DRD3 (0.43) | HTR4KDM1APIK3CDSIGMAR1DRD3 | |
| SCHEMBL23823660 | 0.77 | CYP1A2 (0.64) | KDM1APIK3CDSIGMAR1DRD3ALDH1A1 | |
| SCHEMBL16005740 | 0.76 | HTR4 (0.41) | HTR4ALDH1A1CYP1A2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848716-A1 | CRYSTALLINE FORM OF AN INDAZOLE-CARBOXAMIDE COMPOUND | Theravance, Inc. (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1718643-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2006088988-A1 | CRYSTALLINE FORM OF AN INDAZOLE-CARBOXAMIDE COMPOUND | THERAVANCE, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| WO-2005080389-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2005-09-01 | — | — | WO | disclosed |