Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191000 | 0.87 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5193627 | 0.84 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4992230 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4992218 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5191708 | 0.79 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5607483 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5207285 | 0.77 | TUBB4A (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5207291 | 0.77 | TUBB4A (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5606774 | 0.77 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8373483 | 0.76 | TUBB1 (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |