SCHEMBL5193884

SCHEMBL5193884

Cc1cc(CCCC=O)c2nc(C)c(-c3sc(-c4ncnn4C)cc3Cl)n2n1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 1/20 0.31
CRHR2 Q13324 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3920539 0.80 CRHR1 (0.33) CRHR1CRHR2
SCHEMBL3921107 0.78 CRHR1 (0.51) CRHR1CRHR2
SCHEMBL3921873 0.77 CRHR1 (0.33) CRHR1CRHR2
SCHEMBL3925838 0.76 CRHR1 (0.44) CRHR1CRHR2
SCHEMBL3930704 0.76 CRHR1 (0.33) CRHR1CRHR2
SCHEMBL3924527 0.74 KDM4E (0.33)
SCHEMBL3922567 0.70 CRHR1 (0.41) CRHR1CRHR2
SCHEMBL3931254 0.68 CRHR1 (0.52) CRHR1CRHR2
SCHEMBL3920609 0.68 CRHR1 (0.51) CRHR1CRHR2
SCHEMBL545659 0.68 CRHR1 (0.39) CRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869049-A1 IMIDAZOPYRIDAZINE COMPOUNDS ELI LILLY AND COMPANY (US) 2007-12-26 EP disclosed
WO-2006102194-A1 IMIDAZOPYRIDAZINE COMPOUNDS ELI LILLY AND COMPANY (US) 2006-09-28 WO disclosed