Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.63 |
| ▸ | CDK2 | P24941 | 13/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194082 | 1.00 | FLT3 (0.63) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL5192977 | 0.92 | FLT3 (0.64) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL7457997 | 0.92 | FLT3 (0.64) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL5626655 | 0.90 | FLT3 (0.59) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL5626659 | 0.90 | FLT3 (0.59) | FLT3CDK2PDGFRACDK1CCNE1 | |
| Hydrochloric Acid SCHEMBL27555064 | 0.89 | FLT3 (0.58) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL5195802 | 0.89 | CDK2 (0.69) | FLT3CDK2PDGFRACDK1CCNE1 | |
| SCHEMBL5195796 | 0.89 | CDK2 (0.69) | FLT3CDK2PDGFRACDK1CCNE1 | |
| Hydrochloric Acid SCHEMBL5627238 | 0.88 | CDK2 (0.68) | FLT3CDK2PDGFRACDK1CCNE1 | |
| Hydrochloric Acid SCHEMBL5627242 | 0.88 | CDK2 (0.68) | FLT3CDK2PDGFRACDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500407-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | claimed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | claimed |
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | disclosed |
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | disclosed |