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SCHEMBL5194407

SCHEMBL5194407

CCOc1cc(C2CC(=O)N(C(C)C(=O)O)C2)ccc1OC.COc1ccc(C2CC(=O)N(C(C)C(=O)O)C2)cc1OCc1ccccc1.COc1ccc(C2CC(=O)N(C3CCCC3)C2)cc1OC1CCCC1.COc1ccc(C2CC(=O)N(CC#N)C2)cc1OC1CCCC1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 12/20 0.53
▸ PDE4B Q07343 14/20 0.47
▸ PDE4C Q08493 7/20 0.47
▸ PDE4D Q08499 7/20 0.47
▸ LMNA P02545 1/20 0.39
▸ TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4468650 0.79 PDE4A (0.57) PDE4APDE4BPDE4CPDE4D
SCHEMBL3549613 0.76 PDE4A (0.71) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL4462117 0.76 PDE4A (0.53) PDE4APDE4BPDE4CPDE4DTP53
SCHEMBL3549032 0.73 PDE4A (0.75) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL7368534 0.72 PDE4A (0.79) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3542641 0.71 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL5760778 0.71 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3541761 0.71 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3550628 0.69 PDE4A (0.73) PDE4APDE4BPDE4CPDE4D
SCHEMBL3542007 0.69 PDE4A (0.73) PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1802615-A1 PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2007-07-04 — — EP disclosed
WO-2006044955-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2006-04-27 — — WO disclosed