Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.65 |
| ▸ | VEGFA | P15692 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542641 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL3541761 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL5760778 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL7365947 | 0.86 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL3539891 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL5227988 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL3542660 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL3542007 | 0.81 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3550628 | 0.81 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7448224 | 0.81 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DVEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |