Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | CDK1 | P06493 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 12/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458142 | 1.00 | FLT3 (0.62) | FLT3CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL5628796 | 0.99 | FLT3 (0.61) | FLT3CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL27570962 | 0.99 | FLT3 (0.61) | FLT3CDK1CDK2CCNE1PDGFRA | |
| SCHEMBL5195357 | 0.93 | CDK1 (0.61) | FLT3CDK1CDK2CCNE1PDGFRA | |
| SCHEMBL5195354 | 0.93 | CDK1 (0.61) | FLT3CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL5628157 | 0.92 | CDK1 (0.60) | FLT3CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL5628160 | 0.92 | CDK1 (0.60) | FLT3CDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7460046 | 0.86 | CDK2 (0.70) | FLT3CDK1CDK2CCNE1PDGFRA | |
| SCHEMBL5197008 | 0.86 | CDK2 (0.70) | FLT3CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL5628928 | 0.85 | CDK2 (0.69) | FLT3CDK1CDK2CCNE1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | disclosed |