Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.70 |
| ▸ | FLT3 | P36888 | 3/20 | 0.68 |
| ▸ | CDK1 | P06493 | 5/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197008 | 1.00 | CDK2 (0.70) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| Hydrochloric Acid SCHEMBL5628928 | 0.99 | CDK2 (0.69) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| Hydrochloric Acid SCHEMBL27560215 | 0.99 | CDK2 (0.69) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| SCHEMBL5195802 | 0.91 | CDK2 (0.69) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| SCHEMBL5195796 | 0.91 | CDK2 (0.69) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| Hydrochloric Acid SCHEMBL5627242 | 0.91 | CDK2 (0.68) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| Hydrochloric Acid SCHEMBL5627238 | 0.91 | CDK2 (0.68) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| SCHEMBL5192977 | 0.89 | FLT3 (0.64) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| SCHEMBL7457997 | 0.89 | FLT3 (0.64) | CDK2CCNE1PDGFRAFLT3CDK1 | |
| Hydrochloric Acid SCHEMBL27541607 | 0.89 | CDK1 (0.67) | CDK2CCNE1PDGFRAFLT3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | disclosed |