Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.73 |
| ▸ | CDK1 | P06493 | 14/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.73 |
| ▸ | FLT3 | P36888 | 7/20 | 0.73 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.73 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.73 |
| ▸ | CDK4 | P11802 | 4/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.73 |
| ▸ | CCND1 | P24385 | 4/20 | 0.73 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.73 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CCNH | P51946 | 1/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945583 | 0.89 | CDK2 (0.79) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL6945271 | 0.88 | CDK2 (0.78) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL6945276 | 0.88 | CDK2 (0.78) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL27479416 | 0.88 | CDK2 (0.78) | CDK2CDK1CCNE1FLT3CCNE2 | |
| SCHEMBL5194936 | 0.86 | CDK2 (0.85) | CDK2CDK1CCNE1FLT3CCNE2 | |
| SCHEMBL5195307 | 0.86 | CDK2 (0.85) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL6821008 | 0.86 | CDK2 (0.81) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL6821007 | 0.86 | CDK2 (0.81) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL5195826 | 0.85 | CDK2 (0.83) | CDK2CDK1CCNE1FLT3CCNE2 | |
| Hydrochloric Acid SCHEMBL5195830 | 0.85 | CDK2 (0.83) | CDK2CDK1CCNE1FLT3CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | claimed |