Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 17/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195453 | 1.00 | PYGL (0.59) | PYGLCTSLCYP2C9CNR1CNR2 | |
| SCHEMBL5192639 | 0.99 | PYGL (0.57) | PYGLCTSLCYP2C9CNR1CNR2 | |
| SCHEMBL5191862 | 0.88 | PYGL (0.55) | PYGLCYP2C9 | |
| SCHEMBL5192299 | 0.85 | PYGL (0.51) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5192292 | 0.85 | PYGL (0.51) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5195691 | 0.85 | PYGL (0.53) | PYGLCYP2C9 | |
| SCHEMBL5194685 | 0.85 | PYGL (0.46) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5195696 | 0.85 | PYGL (0.53) | PYGLCYP2C9 | |
| SCHEMBL5197270 | 0.85 | PYGL (0.46) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5427731 | 0.85 | PYGL (0.48) | PYGLCYP2C9CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |