Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976100 | 0.83 | CYP3A4 (0.58) | CYP3A4TSHRTP53GAAMCOLN3 | |
| SCHEMBL9001683 | 0.81 | ALDH1A1 (0.64) | CYP3A4TSHRTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL14743558 | 0.78 | ALDH1A1 (0.45) | CYP3A4TSHRTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL3067512 | 0.76 | TSHR (0.47) | TSHRTP53GAASMN1; SMN2KMT2A | |
| SCHEMBL1006444 | 0.76 | HTT (0.71) | TSHRTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3462834 | 0.75 | NPSR1 (0.67) | CYP3A4TSHRTP53ALDH1A1MEN1 | |
| SCHEMBL14743719 | 0.74 | ALDH1A1 (0.42) | TSHRTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3454767 | 0.73 | MEN1 (0.70) | CYP3A4TSHRTP53ALDH1A1MEN1 | |
| SCHEMBL2025626 | 0.73 | TSHR (0.42) | TSHRTP53GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL11670709 | 0.73 | TSHR (0.71) | CYP3A4TSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797083-A1 | SULFONAMIDE COMPOUNDS | Janssen Pharmaceutica, N.V. (BE) | 2007-06-20 | — | — | EP | claimed |
| WO-2006036670-A1 | SULFONAMIDE COMPOUNDS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | claimed |