Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195592 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL5195582 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL5416978 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL6349002 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL5416980 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL2156827 | 0.86 | MEN1 (0.47) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL2156823 | 0.86 | MEN1 (0.47) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL4245008 | 0.84 | CA12 (0.50) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL4245012 | 0.84 | CA12 (0.50) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL5194570 | 0.84 | CTSS (0.47) | SMN1; SMN2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |