Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 17/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 17/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 17/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.68 |
| ▸ | RAF1 | P04049 | 7/20 | 0.68 |
| ▸ | GCGR | P47871 | 11/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198712 | 0.88 | TEK (0.48) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5921859 | 0.82 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469111 | 0.82 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5199957 | 0.82 | MAPK14 (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL28008186 | 0.81 | MEN1 (0.51) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| Methyl Alcohol SCHEMBL27727314 | 0.79 | FABP4 (0.53) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5197416 | 0.79 | MEN1 (0.54) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5200686 | 0.78 | KDM4E (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2649730 | 0.78 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6471005 | 0.78 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |