SCHEMBL5196436

SCHEMBL5196436

CNC(=O)c1ccc(C(F)(F)F)cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
AVPR2 P30518 1/20 0.54
GPR27 Q9NS67 1/20 0.54
CFTR P13569 1/20 0.51
KDM4E B2RXH2 2/20 0.50
CYP2C19 P33261 2/20 0.50
USP2 O75604 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
HSD17B10 Q99714 1/20 0.50
SLC6A9 P48067 1/20 0.49
PLK1 P53350 1/20 0.49
PPARA Q07869 2/20 0.47
RXFP1 Q9HBX9 2/20 0.47
HTT P42858 1/20 0.47
SCN8A Q9UQD0 2/20 0.47
SCN10A Q9Y5Y9 2/20 0.47
MCHR1 Q99705 1/20 0.46
NCS1 P62166 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26795955 0.86 NR1H4 (0.59) NPC1RAB9AKDM4ECYP2C19ALDH1A1
SCHEMBL24901813 0.84 CFTR (0.67) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL20384958 0.82 KDM4E (0.58) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL422034 0.82 ALDH1A1 (0.71) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL27171750 0.81 DUSP3 (0.46) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL1003490 0.81 CFTR (0.54) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL426613 0.81 KDM4E (0.53) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL422122 0.80 NPC1 (0.53) NPC1RAB9AAVPR2GPR27CFTR
SCHEMBL4797114 0.80 KDM4E (0.51) NPC1RAB9ACFTRKDM4ECYP2C19
SCHEMBL13407781 0.79 KDM4E (0.64) GPR27CFTRKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2742024-A1 COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (ELECTRON WITHDRAWING GROUPS) Georgia Tech Research Corporation (US) 2014-06-18 EP disclosed
WO-2013023107-A1 COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (ELECTRON WITHDRAWING GROUPS) GEORGIA TECH RESEARCH CORPORATION (US) 2013-02-14 WO disclosed
WO-2013023109-A1 COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (COUPLED TRICYCLIC CORE COMPOUNDS) GEORGIA TECH RESEARCH CORPORATION (US) 2013-02-14 WO disclosed
WO-2013023106-A1 COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (ACYL MOIETIES) GEORGIA TECH RESEARCH CORPORATION (US) 2013-02-14 WO disclosed
WO-2013023108-A1 COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (HETEROARYLENE SPACER MOIETY) GEORGIA TECH RESEARCH CORPORATION (US) 2013-02-14 WO disclosed
EP-1737840-A1 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2007-01-03 EP disclosed
WO-2005103033-A1 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2005-11-03 WO disclosed