Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5304121 | 0.91 | GPR119 (0.46) | GPR119CHRM2CHRM1MAPTKMT2A | |
| SCHEMBL5223968 | 0.89 | CHRM2 (0.49) | GPR119CHRM2CHRM1MAPTKMT2A | |
| SCHEMBL5228645 | 0.88 | CHRM2 (0.48) | GPR119CHRM2CHRM1MAPTKMT2A | |
| SCHEMBL5198989 | 0.87 | CHRM2 (0.46) | GPR119CHRM2CHRM1MAPTKMT2A | |
| SCHEMBL4894091 | 0.86 | GPR119 (0.49) | GPR119 | |
| SCHEMBL5198338 | 0.83 | CHRM2 (0.51) | GPR119CHRM2CHRM1MAPTKMT2A | |
| SCHEMBL13989739 | 0.82 | HTR2C (0.45) | KMT2AALDH1A1HTR2CHTR2B | |
| SCHEMBL13989746 | 0.81 | HTR2C (0.48) | KMT2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL4900657 | 0.81 | HTR2C (0.44) | KMT2AALDH1A1HTR2CHTR2B | |
| SCHEMBL13989769 | 0.81 | HTR2C (0.46) | KMT2ASMN1; SMN2HTTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |