Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196705 | 0.91 | SDHB (0.48) | SDHBTERTMKNK1MKNK2PDE5A | |
| SCHEMBL5445065 | 0.79 | SDHB (0.54) | SDHBPDE5ALMNAHRH3KMT2A | |
| SCHEMBL5442844 | 0.78 | CYP11B1 (0.55) | SDHBPDE5AKMT2AMEN1 | |
| SCHEMBL16275125 | 0.78 | KDR (0.46) | SDHBPDE5AHRH3GRM2 | |
| SCHEMBL5198716 | 0.77 | SDHB (0.45) | SDHBPDE5ANPBWR1HRH3KMT2A | |
| Hydrochloric Acid SCHEMBL5441463 | 0.77 | KDR (0.46) | SDHBPDE5AHRH3GRM2 | |
| SCHEMBL5435867 | 0.77 | SDHB (0.50) | SDHBPDE5ANPBWR1LMNAGRM2 | |
| SCHEMBL5183369 | 0.76 | SDHB (0.45) | SDHBPDE5ANPBWR1L3MBTL1HRH3 | |
| SCHEMBL8265074 | 0.75 | SDHB (0.57) | BACE1SDHBMKNK1MKNK2GRM2 | |
| SCHEMBL5185016 | 0.75 | SDHB (0.43) | SDHBPDE5ANPBWR1HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006030032-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-23 | — | — | WO | disclosed |