Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21331828 | 0.84 | ALDH1A1 (0.49) | TYMPSMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL1443962 | 0.79 | TYMP (0.46) | TYMPNR3C1NR3C2SMN1; SMN2ALDH1A1 | |
| SCHEMBL5197709 | 0.79 | TYMP (0.38) | TYMPNR3C1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9138375 | 0.77 | TYMP (0.40) | TYMPNR3C1SMN1; SMN2DAOALDH1A1 | |
| SCHEMBL21331827 | 0.76 | SMN1; SMN2 (0.46) | TYMPNR3C1SMN1; SMN2DAOALDH1A1 | |
| SCHEMBL7255104 | 0.76 | ALDH1A1 (0.67) | TYMPNR3C1DAOALDH1A1 | |
| SCHEMBL20828256 | 0.76 | TYMP (0.65) | TYMPNR3C1NR3C2SMN1; SMN2DAO | |
| SCHEMBL27711724 | 0.76 | TYMP (0.51) | TYMPNR3C1NR3C2DAOALDH1A1 | |
| SCHEMBL27711723 | 0.76 | TYMP (0.51) | TYMPNR3C1NR3C2DAOALDH1A1 | |
| SCHEMBL1287916 | 0.75 | TYMP (0.47) | TYMPNR3C1NR3C2DAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355887-B1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIV GENEVE (CH) | 2007-08-15 | — | — | EP | disclosed |
| US-6911450-B1 | Pyrimidine acyclonucleoside derivatives, preparation method and use thereof | UNIVERSITE DE GENEVE (CH) | 2005-06-28 | — | — | US | disclosed |
| EP-1355887-A1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002060880-A1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2002-08-08 | — | — | WO | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-0736015-B1 | ANTIVIRAL 2,4-PYRIMIDINDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RES INST CHEM TECH (KR) | 2001-03-07 | — | — | EP | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
| US-5747500-A | VIRICIDES FOR AIDS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1998-05-05 | — | — | US | disclosed |
| EP-0736015-A1 | NOVEL ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995018109-A1 | NOVEL ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1995-07-06 | — | — | WO | disclosed |