Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3539215 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL4462030 | 0.93 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5762460 | 0.90 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5760783 | 0.90 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL3554682 | 0.89 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5194095 | 0.88 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3541907 | 0.88 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5757932 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL3542915 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5807740 | 0.83 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613590-A2 | 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | claimed |
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |