Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542915 | 1.00 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5762460 | 0.91 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5760783 | 0.91 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL4462030 | 0.88 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5194231 | 0.87 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL3544886 | 0.87 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL3539215 | 0.86 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5197256 | 0.86 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL5194511 | 0.85 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL3551154 | 0.85 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613590-A2 | 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |