Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097028 | 1.00 | GPR119 (0.43) | GPR119TGFBR1STSBACE1PDE4B | |
| SCHEMBL5091022 | 0.87 | MAPT (0.37) | ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL5097502 | 0.83 | GPR119 (0.49) | GPR119TGFBR1 | |
| SCHEMBL5096953 | 0.80 | GPR119 (0.43) | GPR119TGFBR1STSBACE1PDE4B | |
| SCHEMBL2277132 | 0.72 | PDE4B (0.64) | GPR119STSPDE4BPDE4APDE4C | |
| SCHEMBL31583988 | 0.72 | PDE4B (0.64) | GPR119STSPDE4BPDE4APDE4C | |
| SCHEMBL1015417 | 0.71 | PDE4B (0.57) | STSPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1015416 | 0.71 | PDE4B (0.57) | STSPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1018705 | 0.71 | PDE4B (0.57) | STSPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4854592 | 0.70 | MEN1 (0.64) | GPR119PDE4BALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836196-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069275-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |