Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412779 | 0.91 | HRH3 (0.48) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL28287189 | 0.89 | CHRNA7 (0.46) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL2603303 | 0.83 | CHRNA7 (0.49) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL26205628 | 0.83 | HRH3 (0.59) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL14866471 | 0.82 | CHRM1 (0.52) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL23384238 | 0.80 | CHRNA7 (0.46) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL4668594 | 0.79 | HRH3 (0.55) | CHRM1HRH3KCNH2CYP2D6 | |
| SCHEMBL24317826 | 0.79 | CHRNA7 (0.53) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL21809205 | 0.79 | ALDH1A1 (0.55) | — | |
| SCHEMBL12026534 | 0.79 | CYP1A2 (0.46) | CHRM1CHRNA7HRH3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763978-B1 | CARBAMATE/ UREA DERIVATIVES CONTAINING PIPERIDIN AND PIPERAZIN RINGS AS H3 RECEPTOR INHIBITORS | NOVARTIS AG (CH) | 2017-02-01 | — | — | EP | claimed |
| EP-1802307-A1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LIMITED (GB) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040192-A1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-04-20 | — | — | WO | disclosed |