Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014600 | 0.81 | PTGS2 (0.39) | PTGS2ENPP1PTGS1RPS6KA3DAPK3 | |
| SCHEMBL2012242 | 0.79 | MAPK1 (0.38) | PTGS2MAPK1PTGS1TP53 | |
| SCHEMBL2430751 | 0.77 | PTGS2 (0.39) | PTGS2CYP2A6ENPP1PTGS1RPS6KA3 | |
| SCHEMBL9559722 | 0.76 | PTGS2 (0.40) | PTGS2PTGS1MAPK14ALDH1A1SLC6A4 | |
| SCHEMBL9559797 | 0.75 | PTGS2 (0.39) | PTGS2PTGS1MAPK14SLC6A4SLC6A3 | |
| SCHEMBL20108650 | 0.72 | TYMP (0.42) | PTGS2CYP2A6MAPK14NOS3TP53 | |
| SCHEMBL9788256 | 0.71 | PTGS2 (0.40) | PTGS2ENPP1PTGS1RPS6KA3DAPK3 | |
| SCHEMBL15635850 | 0.71 | CYP2A6 (0.33) | CYP2A6FGFR1PDK2 | |
| SCHEMBL2161599 | 0.70 | CYP2A6 (0.65) | PTGS2CYP2A6PTGS1ALDH1A1PDK2 | |
| SCHEMBL7458982 | 0.70 | CYP2A6 (0.59) | PTGS2CYP2A6MAPK1PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814863-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052190-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |