Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999415 | 0.77 | HPGD (0.48) | SMN1; SMN2TSHRGAAHPGDL3MBTL1 | |
| SCHEMBL2001526 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRGAAHPGDLMNA | |
| SCHEMBL2001043 | 0.72 | ASAH1 (0.41) | SMN1; SMN2HIF1AKDM4E | |
| SCHEMBL1997463 | 0.71 | HPGD (0.36) | SMN1; SMN2GAAHPGDALDH1A1KDM4E | |
| SCHEMBL5200606 | 0.70 | MEN1 (0.38) | SMN1; SMN2TSHRGAAHPGDLMNA | |
| SCHEMBL2000476 | 0.68 | CA12 (0.40) | ACHEMAPK1 | |
| SCHEMBL5185942 | 0.68 | ACHE (0.43) | GAAHPGDL3MBTL1ACHEALDH1A1 | |
| SCHEMBL2000223 | 0.67 | CA12 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1998233 | 0.66 | CA12 (0.45) | SMN1; SMN2GAAACHEALDH1A1KMT2A | |
| SCHEMBL19127183 | 0.66 | CA12 (0.40) | SMN1; SMN2TSHRGAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |