Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.52 |
| ▸ | GAA | P10253 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 7/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356628 | 0.89 | NOTCH1 (0.76) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL13461463 | 0.87 | KDM4E (0.61) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL3320306 | 0.84 | NOTCH1 (0.72) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL3322525 | 0.83 | NOTCH1 (1.00) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL15756118 | 0.80 | KDM4E (0.61) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL7764271 | 0.79 | HTT (0.62) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL3009364 | 0.79 | KDM4E (0.68) | NOTCH1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL27517413 | 0.78 | CACNA1B (0.65) | — | |
| SCHEMBL742561 | 0.78 | GAA (0.57) | KDM4EGAAALDH1A1HPGDGLA | |
| SCHEMBL5222988 | 0.77 | GSK3B (0.58) | KDM4EGAAALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814554-A1 | CERTAIN COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-08-08 | — | — | EP | claimed |
| US-20060116369-A1 | Certain compounds, compositions, and methods | CYTOKINETICS, INC. | 2006-06-01 | — | — | US | claimed |
| WO-2006047537-A1 | CERTAIN COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2006-05-04 | — | — | WO | claimed |
| EP-1814554-A1 | CERTAIN COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20060116369-A1 | Certain compounds, compositions, and methods | CYTOKINETICS, INC. | 2006-06-01 | — | — | US | disclosed |
| WO-2006047537-A1 | CERTAIN COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116369-A1 | Certain compounds, compositions, and methods | PCNA, MKI67, TP53 | NOTCH1 823/4885KDM4E 4051/4885GAA 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.