Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.54 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17329111 | 0.89 | IDO1 (0.59) | IDO1DAOMAOBKDM4EALDH1A1 | |
| SCHEMBL8526001 | 0.82 | TAAR1 (0.75) | TAAR1IDO1DAOMAOBAOC3 | |
| SCHEMBL1011004 | 0.81 | MAOB (0.57) | TAAR1IDO1DAOMAOBKDM4E | |
| SCHEMBL29915506 | 0.81 | MAOB (0.57) | TAAR1IDO1DAOMAOBKDM4E | |
| Iodide SCHEMBL28682742 | 0.79 | MAOB (0.55) | TAAR1IDO1DAOMAOBKDM4E | |
| SCHEMBL17671285 | 0.79 | KDM4E (0.54) | IDO1DAOMAOBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6944674 | 0.79 | MAOB (0.59) | TAAR1IDO1DAOMAOBKDM4E | |
| SCHEMBL2089439 | 0.78 | IDO1 (0.53) | IDO1DAOMAOBKDM4EALDH1A1 | |
| SCHEMBL2096671 | 0.78 | IDO1 (0.53) | TAAR1IDO1DAOMAOBKDM4E | |
| SCHEMBL3978648 | 0.77 | IDO1 (0.52) | IDO1DAOMAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814863-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052190-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |