Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287916 | 0.79 | TYMP (0.47) | TYMPHPGDMAPTALDH1A1HTT | |
| SCHEMBL5197709 | 0.76 | TYMP (0.38) | TYMPPDE3BPDE3AIDH1HPGD | |
| SCHEMBL20886374 | 0.72 | KDM4E (0.37) | TYMPPDE3BPDE3AHCAR2MAPT | |
| SCHEMBL6641589 | 0.71 | MAPK8 (0.39) | TYMPHPGDMAPTALDH1A1KMT2A | |
| SCHEMBL7674381 | 0.69 | DAO (0.43) | TYMPHPGDHCAR2MAPTALDH1A1 | |
| SCHEMBL6086504 | 0.69 | TYMP (0.37) | TYMPPDE3BPDE3AHCAR2ALDH1A1 | |
| SCHEMBL501343 | 0.69 | PDE3B (0.38) | TYMPPDE3BPDE3AHCAR2ALDH1A1 | |
| SCHEMBL5888655 | 0.68 | HPGD (0.34) | HPGDKMT2A | |
| SCHEMBL501939 | 0.68 | MAPT (0.37) | TYMPPDE3BPDE3AHPGDHCAR2 | |
| SCHEMBL3925934 | 0.67 | PDE3B (0.30) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355887-B1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIV GENEVE (CH) | 2007-08-15 | — | — | EP | disclosed |
| US-6911450-B1 | Pyrimidine acyclonucleoside derivatives, preparation method and use thereof | UNIVERSITE DE GENEVE (CH) | 2005-06-28 | — | — | US | disclosed |
| EP-1355887-A1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2003057677-A1 | ANTI-RETROVIRAL 5,6-DISUBSTITUTED ACYCLOPYRIMIDINE NUCLEOSIDE DERIVATIVES | SYDDANSK UNIVERSITET (DK) | 2003-07-17 | — | — | WO | disclosed |
| WO-2002060880-A1 | PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2002-08-08 | — | — | WO | disclosed |
| EP-0736015-B1 | ANTIVIRAL 2,4-PYRIMIDINDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RES INST CHEM TECH (KR) | 2001-03-07 | — | — | EP | disclosed |
| US-5747500-A | VIRICIDES FOR AIDS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1998-05-05 | — | — | US | disclosed |
| EP-0736015-A1 | NOVEL ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995018109-A1 | NOVEL ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1995-07-06 | — | — | WO | disclosed |