Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828486 | 0.82 | GRM5 (0.33) | GRM5HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2826274 | 0.75 | GRM5 (0.46) | GRM5HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5185506 | 0.74 | GRM5 (0.47) | GRM5NPC1RAB9A | |
| SCHEMBL5199075 | 0.73 | GRM5 (0.47) | GRM5HDAC1NPC1RAB9A | |
| SCHEMBL5199983 | 0.71 | GRM5 (0.46) | GRM5HDAC1NPC1RAB9A | |
| SCHEMBL2829709 | 0.68 | CSNK2A1 (0.43) | GRM5NPC1RAB9A | |
| SCHEMBL2831219 | 0.66 | NPC1 (0.37) | GRM5NTRK1NPC1RAB9A | |
| SCHEMBL2830963 | 0.65 | CSNK2A1 (0.45) | GRM5 | |
| SCHEMBL3527323 | 0.65 | GRM5 (0.37) | GRM5HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5198047 | 0.65 | GRM5 (0.64) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |