Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.47 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828458 | 0.86 | ACSS2 (0.36) | GRM5ACSS2LMNASMN1; SMN2NPC1 | |
| SCHEMBL5199983 | 0.84 | GRM5 (0.46) | GRM5LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5204048 | 0.82 | PDE10A (0.47) | GRM5ACSS2LMNASMN1; SMN2NPC1 | |
| SCHEMBL2831104 | 0.78 | GRM5 (0.37) | GRM5ACSS2LMNASMN1; SMN2NPC1 | |
| SCHEMBL5204681 | 0.75 | PDE10A (0.42) | GRM5ACSS2 | |
| SCHEMBL5201681 | 0.75 | PDE10A (0.47) | GRM5ACSS2LMNASMN1; SMN2NPC1 | |
| SCHEMBL5207920 | 0.74 | PDE10A (0.51) | GRM5ACSS2LMNASMN1; SMN2NPC1 | |
| SCHEMBL5199566 | 0.73 | GRM5 (0.48) | GRM5NPC1RAB9AHDAC1 | |
| SCHEMBL5200364 | 0.73 | GRM5 (0.46) | GRM5NPC1RAB9A | |
| SCHEMBL2825835 | 0.71 | SLC34A1 (0.34) | GRM5NPC1RAB9ATP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |