Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | QDPR | P09417 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 6/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908137 | 0.85 | NAMPT (0.44) | — | |
| SCHEMBL5199936 | 0.80 | HDAC1 (0.38) | CSF1RQDPRHDAC1HDAC2HDAC3 | |
| Trifluoroacetic Acid SCHEMBL3093603 | 0.78 | CSF1R (0.50) | CSF1RQDPRGRM2KIT | |
| SCHEMBL3080853 | 0.78 | CSF1R (0.51) | CSF1RQDPR | |
| SCHEMBL16262649 | 0.76 | HDAC1 (0.49) | QDPRHDAC1HDAC2HDAC3KCNH2 | |
| SCHEMBL12478958 | 0.75 | QDPR (0.48) | QDPRHDAC1HDAC2HDAC3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL3073799 | 0.75 | KIT (0.46) | CSF1RKCNH2CYP2C19KIT | |
| SCHEMBL27847470 | 0.74 | QDPR (0.49) | CSF1RQDPRHDAC1HDAC2HDAC3 | |
| SCHEMBL25216280 | 0.74 | CSF1R (0.37) | CSF1RGRM2NR1I2KCNH2 | |
| SCHEMBL27691389 | 0.74 | GAA (0.51) | CSF1RQDPRHDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807077-B1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-23 | — | — | EP | disclosed |
| EP-1807077-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047277-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |