SCHEMBL5200141

SCHEMBL5200141

NC(O)(CCO)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.48
HIF1A Q16665 1/20 0.48
SLC6A2 P23975 1/20 0.48
TAAR1 Q96RJ0 1/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
TDP1 Q9NUW8 1/20 0.43
FDPS P14324 1/20 0.42
TSHR P16473 1/20 0.41
ARG1 P05089 1/20 0.39
ARG2 P78540 1/20 0.39
KDM4E B2RXH2 2/20 0.39
POLB P06746 1/20 0.39
KCNA5 P22460 1/20 0.37
LMNA P02545 2/20 0.36
CYP2D6 P10635 1/20 0.36
TRPA1 O75762 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.36
MAOA P21397 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2778837 0.83 SMN1; SMN2 (0.48) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL8643657 0.82 SLC6A2 (0.52) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL20495946 0.81 HIF1A (0.50) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
Water SCHEMBL18127929 0.79 HIF1A (0.48) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
Fluoride SCHEMBL9441193 0.79 HIF1A (0.48) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
Hydrochloric Acid SCHEMBL9306291 0.79 SMN1; SMN2 (0.48) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL14935111 0.78 CYP2C19 (0.50) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL9271997 0.78 TAAR1 (0.58) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL15637553 0.78 SLC6A2 (0.57) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2
SCHEMBL11141085 0.77 SLC6A2 (0.56) SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673078-A4 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE MERCK & CO INC (US) 2007-04-18 EP disclosed
EP-1673078-A2 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE Merck & Co., Inc. (US) 2006-06-28 EP disclosed
WO-2005032471-A2 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE MERCK & CO., INC. (US) 2005-04-14 WO disclosed