Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.84 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825932 | 0.88 | GRM5 (0.79) | GRM5NAMPT | |
| SCHEMBL2846654 | 0.87 | GRM5 (1.00) | GRM5NAMPT | |
| SCHEMBL2846652 | 0.85 | GRM5 (0.81) | GRM5NAMPTLCKJAK2JAK3 | |
| SCHEMBL2830049 | 0.84 | GRM5 (0.60) | GRM5NAMPTJAK2JAK3 | |
| SCHEMBL2827469 | 0.79 | GRM5 (0.77) | GRM5NAMPT | |
| SCHEMBL5199705 | 0.78 | GRM5 (0.70) | GRM5NAMPT | |
| SCHEMBL2827669 | 0.78 | GRM5 (0.65) | GRM5 | |
| SCHEMBL2825984 | 0.78 | GRM5 (0.69) | GRM5NAMPT | |
| SCHEMBL2829293 | 0.77 | GRM5 (0.74) | GRM5NAMPT | |
| SCHEMBL2826680 | 0.76 | GRM5 (0.66) | GRM5NAMPTJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |