Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.70 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198047 | 0.89 | GRM5 (0.64) | GRM5NPC1RAB9ASMN1; SMN2PDE10A | |
| SCHEMBL5197860 | 0.84 | GRM5 (0.49) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2827684 | 0.83 | GRM5 (0.48) | GRM5NAMPTNPC1RAB9ATSHR | |
| SCHEMBL2846654 | 0.82 | GRM5 (1.00) | GRM5NAMPT | |
| SCHEMBL5197589 | 0.81 | GRM5 (0.52) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5200154 | 0.81 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL2846652 | 0.80 | GRM5 (0.81) | GRM5NAMPTSMN1; SMN2 | |
| SCHEMBL5208137 | 0.80 | GRM5 (0.72) | GRM5NAMPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12595512 | 0.80 | PDE10A (0.52) | GRM5NAMPTNPC1RAB9APDE10A | |
| SCHEMBL5200364 | 0.79 | GRM5 (0.46) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |