Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 8/20 | 0.45 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339257 | 0.91 | TGFBR1 (0.46) | TGFBR1ACVR1BACVR1TGFBR2MAP3K20 | |
| SCHEMBL4334304 | 0.91 | TGFBR1 (0.45) | TGFBR1ACVR1BACVR1TGFBR2MAP3K20 | |
| SCHEMBL4350318 | 0.91 | TGFBR1 (0.55) | TGFBR1ACVR1BACVR1TGFBR2MAP3K20 | |
| SCHEMBL4350435 | 0.84 | TGFBR1 (0.49) | TGFBR1ACVR1BMAPK14 | |
| SCHEMBL4347711 | 0.79 | TGFBR1 (0.70) | TGFBR1ACVR1BMAPK14KDM4E | |
| SCHEMBL4332553 | 0.76 | TGFBR1 (0.55) | TGFBR1MAPK14 | |
| SCHEMBL4343678 | 0.74 | TGFBR1 (0.51) | TGFBR1ACVR1BMAPK14 | |
| SCHEMBL4339418 | 0.74 | TGFBR1 (0.49) | TGFBR1ACVR1BMAPK14 | |
| SCHEMBL4339282 | 0.74 | TGFBR1 (0.62) | TGFBR1ACVR1BMAPK14 | |
| SCHEMBL4337372 | 0.70 | TGFBR1 (0.69) | TGFBR1ACVR1BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |